A clot is simply a mass of fibrin threads with a large number of corpuscles tangled within.
In blood within the circulatory system of the body, the fibrin is held in a fluid state called fibrinogen.
An enzyme, acting upon this fibrinogen, the soluble protein in the blood, causes it to change to an insoluble form, the fibrin of the clot.
This change takes place when blood leaves the arteries, and the fibrin thus formed occasions the clotting which ensues (see BLOOD).
The usual method of beating a blood-clot with twigs and removing the filamentous fibrin which attaches itself to them yields a very impure product containing haemoglobin and much globulin; moreover, it is very difficult to purify.
To obtain pure coagulated fibrin it is best to heat blood-plasma (preferably that of the horse) to 56 deg.
This condition may be followed by a coagulation of fibrin upon the inflamed surface, which adheres to it, and by attrition soon becomes worked up into shreddy-like granular elevations.
The latter form receives its names from the fact that the air spaces are choked with coagulated fibrin thrown out from the blood.
This serum may contain flakes of fibrin and it may be straw colored or red from an admixture of blood.
Occasionally the fibrin may be seen lining one of the cavities of the heart, like a false endocardium, or else forming an additional coat to the aorta or other large vessels without producing much obstruction.
The first stage of the disease consists of congestion, or engorgement, of the blood vessels, followed by leakage of serum containing fibrin from the blood vessels into the air passages.
The cavity of the aneurismal sac is filled with fluid or clotted blood or with layers of fibrinwhich adhere closely to its wall.
This is followed by the formation of a coating of coagulated fibrin on the diseased pleura and the transudation of serum which collects in the chest.
One element has the power to destroy the fibrin ferment in the blood, the other acts as a paralyzant upon motor and sensory nerve trunks.
The idea is that the fibrin in the blood becomes entangled in the fiber of the cotton and sets up a clot that seals the bleeding surface, while the cold water closes the blood supply by its action on the artery supplying the parts.
Next morning he cannot find Papillon, but on opening a door he meets a huge serpent, whom he also slays, and follows a little path which leads him into an orchard "tant bel et tant plaisant, que cestoit ung petit paradis a veoir.
Some old romancers may have spoken only of a queen; and the gallant Sir Thopas does not seem to apprehend that he is in pursuit of the wedded wife of another.
Full many a maidè bright in bour They mourned for him par amour; When hem were bete to slepe; But he was chaste and no lechour, And sweet as is the bramble flour That bereth the red hepe.
Ogier asked permission to encounter this formidable personage, which Arthur willingly granted.
He plucks an apple from one of the trees and eats it, but is immediately afflicted by such violent sickness as to be put in fear of speedy death.
In this fibrin are frequently found bacteria, even when there has been no recent acute inflammation.
Although these little vegetations and excrescences sooner or later become mostly connective tissue, still fibrin and white blood cells may form thin layers over them, more or less permanent.
Whether milk or any other substance containing lime makes fibrin deposits on the ulcerative surfaces more likely or more profuse, and therefore emboli more liable to occur, is perhaps an undeterminable question.
It is doubtful whether ammonium carbonate tends to prevent fibrin deposits or clots in the heart, as so long supposed.
Fibrin readily deposits on this calcareous substance and may form a permanent capping, or may slowly disintegrate and allow fragments to fly off into the blood stream and cause more or less serious embolic obstruction.
EM'BOLUS, the clot of fibrin obstructing a blood-vessel, causing embolism.
When blood coagulates in a serous cavity, a thin pellicle forms upon its surface, and, becoming thickened by deposition from the fibrin of the blood, forms a cyst, which completely circumscribes the effusion.
During the time that the parts are united only by the fibrin from the blood, any violence must tend to produce the same effect.
If there was fibrinand osseous matter in his veins he had given them fair warning.
When a wound is made, and bleeding commences, the fibrin forms a temporary plug, as it were, which is absorbed when the healing process is finished.
All the functions of life are regularly performed in people whose blood lacks fibrin; and, in cases of transfusion, where blood deprived of its fibrin was used, the vivifying influence seemed to be the same.
The plasma also contains fibrin, [Footnote: it is usual to say that fibrin is contained in the blood.
The exact nature of the process by which fibrin is produced by these three factors is not understood--See Foster's Text Book of Physiology, p 22.
Footnote: The fibrin is not an essential ingredient of the blood.
Pure fibrin occurs as long, white, elastic filaments, which are tasteless, inodorous, and insoluble in both hot and cold water.
The deposit of fibrin on the synovial membrane and on the articular surfaces may lead to the formation of adhesions, sometimes in the form of isolated bands, sometimes in the form of a close fibrous union between the bones.
Within a few hours the peritoneal surfaces are glued together by a thin layer offibrin and leucocytes, which is speedily organised and replaced by fibrous tissue.
Clinically, loose bodies composed of fibrin constitute an unimportant addition to the features of the disease with which they are associated.
Extensive clinical reports appeared to justify its acceptance for New and Nonofficial Remedies with Fibrin Ferments and Thromboplastic substances.
Pepsin: solution of small shreds of fresh fibrin in acid media.
For the proteolytic test I used fresh, well washed fibrin and examined samples of Lactopeptine powder numbered as follows: No.
The digestion was practically completed in less than ten minutes, only minute flakes of the fibrin remaining.
The digestion of a few milligrams of fibrin or starch after many hours of contact, while being perhaps scientifically possible, is of no value when we come to a consideration of the use of such bodies as digestive ferments in medicine.
Trypsin: solution of small shreds of fresh fibrin in neutral and alkaline media, and tryptophan test.
At the end of that time there was no marked change in the quantity of the fibrin remaining in each flask, the larger part by far being undigested.
Defn: The fibrin ferment which produces the formation of fibrin from fibrinogen.
Defn: Like fibrinoplastin; capable of forming fibrin when brought in contact with fibrinogen.
Defn: A diminution in the normal amount offibrin present in the blood.
Defn: A toxic alkaloid found occasionally associated with the peptones formed from fibrin by pepsinhydrochloric acid.
An albuminous body, resembling animal fibrin in composition, found in cereal grains and similar seeds; vegetable fibrin.
In a case reported by Matzinger the blood as submitted was black and perfectly fluid, the corpuscles, both red and white, were normal, and no fibrin was detected.
The layer nearest the outer husk contains vegetable fibrin and fatty matter.
The casein is equivalent to the gluten of vegetables or the fibrin of meat, and the sugar to starch.
Grains, fruits and vegetables contain starch and sugar and more or less gluten; meats contain fibrin and albumen; milk, casein, etc.
When this exudate and the necrosed cellular elements come in contact, the latter furnish a fibrin ferment which transforms the exduate into a fibrinous mass.
The filling up of the interlobular spaces withfibrin and connective tissue of inflammatory origin is not thus limited to pleuropneumonia, but may appear in a marked degree in other lung diseases.
When large regions of the lung tissues are hepatized, the main air tube and its branches are usually filled with grayish, cylindrical branched masses of fibrin that are easily removed, as they do not adhere to the mucous membrane.
These consist in the simplest form of a collection of serous fluid mixed with fibrin within a distended bursa.
In individuals of a debilitated condition, it results from the lack of a proper amount of fibrinin the blood.
The amount offibrin should also be increased by the use of the "Golden Medical Discovery.
Like fibrinoplastin; capable of forming fibrin when brought in contact with fibrinogen.
A diminution in the normal amount of fibrin present in the blood.
If, however, the pus and fibrin are produced in large amounts, the endothelium falls off and leaves the surface of the peritoneum bare.
In no case was the fibrin diminished, but in some it was sensibly increased.
This matter consisted of fibrillated fibrin in large quantity; a great number of the cells just described, some grouped, but most separate or single.
The interstices of the loose submucous tissue and the lymphatic vessels are often filled with fibrillated fibrin and scattered blood-corpuscles for a considerable distance around the ulcer.
The question, then, arises, Will the chemical constitution of fibrin permit its conversion into oil?
The former consist of pericarditis, endocarditis, and myocarditis; the latter embrace deposition of fibrin on the valves, temporary incompetence of the mitral or tricuspid valves, and the formation of thrombi in the cavities of the heart.
Chemical tests of tincture of guaiacum, peroxide of hydrogen, and others failed to show the presence of fibrin or albumen.
He says: "The deposition of fibrin occurs before the endothelium presents any changes.
The first contains only the merest trace of albumen, and no fibrin; the second contains an abundance of albumen, and no fibrin; the third contains both albumen and fibrin in abundance, the latter in a fibrillated form.
It is well to test the digestive power of the filtered fluid from the stomach by suspending in the fluid a floccule of washed fibrin and keeping the fluid at a temperature of about 100 degrees F.
If the inflammation is very intense, the pus and fibrin are most abundant; if milder, the changes in the endothelium are more marked.
The alkaline treatment relieves the pain, abates the fever, and saves the heart by lessening the amount of fibrinin the blood.
They do effect a cessation of the local symptoms, render the urine alkaline, and diminish the amount of fibrin in the blood.
The above list will hopefully give you a few useful examples demonstrating the appropriate usage of "fibrin" in a variety of sentences. We hope that you will now be able to make sentences using this word.
