The submaxillary salivary glands and the cervical lymph glands are usually implicated, and the disease tends to spread by metastasis to distant parts.
Metastasis to the liver, lungs, and other viscera is exceptional.
Clinically, the induration and fixation of the tumour suggest its epitheliomatous character, but the absence of a primary growth in the mouth or pharynx excludes its being a metastasis in the lymph glands.
Of sixty-nine bilateral and eighteen unilateral cases of parotitis, metastasis to both testicles occurred in four cases, all of which resulted in atrophy of the affected testicle.
In certain cases,' he says, 'much pus is formed in the lungs, or there is a metastasis from the side if a greater symptom of convalescence be at hand.
Dupuytren failed to produce metastasis by injections of pus into the veins of dogs; these results were confirmed by Boyer, who only obtained metastasis when he used ichorous pus in his experiments.
When metastasis occurs, the return of fever calls for the same general treatment as in the early stage of parotitis.
He speaks of a metastasis to the kidneys and bladder being peculiarly favorable in empyema.
This metastasis occurs much more frequently in males than in females, and is usually met with in pubescents and adults, being very rare either in childhood or old age.
Beck made fourteen experiments very carefully, but did not succeed in producing metastasis in a single case.
The most satisfactory explanation of their presence, and of the generalization, recurrence, or metastasis of tumors, is derived from what has already been stated with reference to the manner of the growth of the latter.
But if that purulent matter does not come out, but being sucked back should be mixed with the humours, it may, being brought to the viscera by a bad metastasis of the morbid matter, give occasion to dangerous disorders.
Thus when the liver is torpid, a perpetual uneasiness and depression of spirits occur; which a fit of gout is supposed to cure by a metastasis of the disease.
Metastasis to the lungs is almost invariably fatal, causing death by asphyxia, Metastasis to the intestines may cause death from pain, enteritis, or hemorrhage.
The sinapism will draw the current of the circulation to the exterior, the metastasis to the lungs or intestines is prevented, and the enfeebled nervous system is stimulated to renewed vigor by the peripheral irritation.
In rare cases the mucous membrane of the nostrils may also become affected, showing yellowish flat elevations and ulcerations, and these may extend by metastasis to internal organs.
When metastasis takes place, as it occasionally does, the fungus is transmitted by the blood vessels, as in pyæmia.
The mode of infection is the same as in the pyogenic diseases of bone, the metastasis occurring most frequently from the mucous membrane of the pharynx (J.
Secondary growths are met with chiefly in the lungs, metastasistaking place by way of the veins.
From the pathological point of view the secondary implication of the liver may be a truemetastasis or a mere communication by contiguity of tissue.
The articular inflammation may continue after the invasion of the meningitis, or the latter may promptly follow the disappearance of the former, as though a metastasis of morbid action had taken place.
Several cases are on record pointing to the possibility of a metastasis of mumps from the parotid gland to the pancreas.
Jaeger in 1770 at Tubingen describes the metastasis of milk to the umbilicus, Haen to the back, and Schurig to a wound in the foot.
Autenreith mentions metastasis of milk through an abdominal abscess to the thigh, and Balthazaar also mentions excretion of milk from the thigh.
Ackerman has spoken of metastasis of the tears, and Dixon gives an instance in which crying was not attended by the visible shedding of tears.
Klein speaks of the metastasis of the milk to the lochia.
Gardane speaks of metastasis to the lungs, and there is another case on record in which this phenomenon caused asphyxia.
The older writers spoke of metastasis of the seminal flow, the issue being by the skin (perspiration) and other routes.
Paullini and the Ephemerides give instances of milk appearing in the perspiration, and there are numerous varieties of milk-metastasis recorded Dolaeus and Nuck mention the appearance of milk in the saliva.
There is the history of a woman who suffered from metastasis of milk to the stomach, and who, with convulsive action of the chest and abdomen, vomited it daily.
Probably the most interesting of all these anomalies is the class in which, by a compensatory process, metastasis of the secretions is noticed.
Metastasis expresses the lawlessness of tumors as regards being limited to the original site of development.
On the other hand, a malignant tumor in its primary growth may so implicate a vital organ as to destroy life before metastasis can occur or even before cachexia can develop.
The gills have become shifted forward by a metastasis similar to that which brought the whole thoracic organs far forward in fish.
We note here an interpretation of the first metastasis in terms of functional adaptation.
A further application of the hypothesis of metastasis will be noticed below in connection with the determination of the sternum of fishes.
It often leaves one part suddenly, and attacks another, either in the neighbourhood, or situated at a considerable distance; in other words, metastasis takes place.
Certain cases would seem to warrant the belief that a species of metastasis occurs; that the matter is absorbed, and again deposited in some other part, perhaps of the utmost importance in the animal economy.
In inflammation of this tissue, metastasis is also apt to occur, from one part of the membrane to another, and from the membrane to the external surface.
Metastasis may take place to the larynx, to the trachea, or to the lungs, either spontaneously, or in consequence of repellent applications.
It is questionable how far it may be safe to apply lunar caustic to any extensively inflamed surface, more especially of the head and face, lest metastasis should occur.
This commensal life may be compared with that of the lichens, in which an organism with vegetable metastasis (the Algoid gonidia) and an organism with animal metastasis (the Fungoid hyphae) are intimately united for mutual benefit.
From the physiological standpoint the Radiolaria appear as unicellular animals, for in this respect the animal character of their metastasis (that proper to an oxidising organism) furnishes the sole {cxxx}criterion.
In case of metastasis to any other organ or part of a carcass, or if metastasis has not occurred, but there are present secondary changes in the muscles .
