Tryptic activity appears likewise to be absent, as in weak alkaline solution after fifteen hours’ digestion no effect on coagulated egg albumin or fibrin was observed when 100 mg.
Albumoses and peptones are obtained by peptic digestion, the latter being termed peptic- peptones; tryptic digestion also produces peptones.
It is practically without interference upon salivary, peptic or tryptic digestion, unless given in large quantities.
Some proteins, the albuminoids and racemized proteins, resist tryptic digestion but yield to acid hydrolysis.
The curd usually diminishes in bulk, due to the gradual digestion or peptonization of the casein by proteid-dissolving enzyms (tryptic type) that are also produced by the bacteria causing the change.
This ferment, called by them galactase, on account of its origin in milk, is a proteolytic enzym of the tryptic type.
Confirmation of this view is afforded by the fact that the addition of a tryptic enzyme of animal origin greatly hastens the disappearance of the alcoholic enzyme [Buchner, E.
Those of Professor Hawk show a tryptic activity of from 18 to 20 per cent.
Even if tryptic activity were conceded to Lactopeptine, the preparation, like all preparations containing pepsin and pancreatin, would still be, as previously stated, therapeutically irrational.
No tests against other preparations possessingtryptic activity are reported, and Dr.
The Elixir Lactopeptine could theoretically show no tryptic activity, nor have I found any trace of such activity in one sample of the Elixir examined.
Bayliss and Starling state that it is destroyed by one hour’s tryptic digestion.
The presence oftryptic activity in two out of the nine samples may be due to the fresher condition of these specimens, as indicated by the serial numbers.
The evidence shows that it is a commercial impossibility to market mixtures of pepsin, pancreatin and lactic acid so that they can display any material tryptic activity.
A few specimens examined by these two referees showed a slight tryptic activity; most of them showed none.
The figures for tryptic activity obtained by the third chemist cited by the manufacturers could not be accepted by the Council, since it was at variance with all other known results of investigations of Lactopeptine.
Hawk and Benedict show a degree of tryptic activity which, though chemically not negligible, is quite without significance practically, even if it could be assumed that the trypsin in the fresh Lactopeptine escaped destruction in the stomach.
The preparation was found to be practically inert--“essentially a weak saccharated pepsin,” devoid of tryptic activity.
The reports of these chemists present no reason for changing the conclusion that “it is a commercial impossibility to market mixtures of pepsin, pancreatin and lactic acid so that they can display any material tryptic activity.
Furthermore, this is not simply a ‘trace’ of activity, but is at least sufficiently marked to warrant a statement that this sample showed a distinct tryptic activity.
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