Theoretically as well as practically, however, pepsin and pancreatin cannot exist together in solution.
The evidence shows that it is a commercial impossibility to market mixtures of pepsin, pancreatin and lactic acid so that they can display any material tryptic activity.
It should be reaffirmed that mixtures combining peptic and pancreatic activities are not feasible, because pepsin cannot act except in the presence of acid, and pancreatin is destroyed by acid and by peptic activity.
Furthermore, in conditions in which pancreatin is called for, pepsin is not, and vice versa; therefore the administration of mixtures of pepsin and pancreatin would be unjustified, even if both constituents could be expected to exert activity.
The outcome of these new investigations showed the essential correctness of the deductions from the older work, namely, that pancreatin is destroyed by pepsin-hydrochloric acid.
The claims made for Elixir Lactopeptine and all other liquid preparations sold as mixtures of pepsin and pancreatin are therefore impossible.
Amongst other wholly extraneous matters, the firm’s “reply” tried to resurrect the pepsin pancreatin controversy.
While mixtures of pepsin and pancreatin are unscientific and unjustified, theoretically the two substances may coexist in a solid preparation, and the activity of such a preparation is consequently a proper subject of investigation.
The reports of these chemists present no reason for changing the conclusion that “it is a commercial impossibility to market mixtures of pepsin, pancreatin and lactic acid so that they can display any material tryptic activity.
When the pancreatic juice is absent pancreatinmay be given in salol-coated pills.
After the stomach is through churning, the partially digested food is moved into the small intestine where it is mixed with more pancreatin secreted by the pancreas, and with bile from the gall bladder.
It is possible to take lactase to break down the milk sugars for example; sometimes aids such as hydrochloric acid, pepsin, and pancreatin help.
This condition is alleviated by eliminating animal proteins from the diet and taking digestive aids such as pancreatin pills with meals to assist in the digestion of vegetable proteins.
Attention to the general health, proper regulation of the diet, and the employment of pancreatin or an infusion of calf's pancreas to supply the place of the deficient pancreatic juice, are the important steps.
The salivary diastase and the pancreatin (containing amylopsin, trypsin, and lipase) were allowed to digest for four days at 38 deg.
Even if such a combination were available, the acidity of the mixture itself and of the gastric juice would in all probability destroy the pancreatin before it could reach the intestinal tract.
Diastase and the amylopsin ofpancreatin seem to be completely absent, or, if present at all, in such minute traces that digestion of starch is not shown after one hour when quantities running from 60 mg.
If the solution be neutral or alkaline the pancreatin gradually destroys the pepsin, and if acid the pepsin destroys the pancreatin.
Test tube experiments show that pepsin hydrolyzes proteins in acid solutions; that pancreatin digests protein in alkaline liquids, and that diastase converts starch into sugar.
Since pepsin and pancreatin interact only when in solution, it is quite possible to prepare tablets which contain these ferments.
Pancreatin has an alkaline reaction, and putrefies very quickly.
To this clear solution is then added a saturated solution of chloride of sodium, and allowed to stand until the pancreatin is separated.
Pancreatin is given for stimulating the digestion of fatty compounds.
With a knowledge of these facts before them, it is not surprising that the employment of pancreatin in disease should have been recommended by therapeutists.
If the ether be afterwards distilled off from the filtered liquid, the pancreatinwill be left as an oily product.
Pancreatin and carbonate of potash, of each 10 gr.
Even when rendered acid, pancreatin does not lose its power of emulsifying fatty bodies.
Control feedings with an emulsion of one-half gram each of pepsin andpancreatin proved inactive.
This amount of the plant was also extracted with water and the residue was then digested with pepsin and pancreatin in the thermostat, as in the previous case, and fed in two doses corresponding to 100 grams each.
The same amount of the dried plant was also similarly digested with pepsin and pancreatin and fed in two doses, but without the production of any symptoms, the rabbit gaining 60 grams in four days.
The above list will hopefully give you a few useful examples demonstrating the appropriate usage of "pancreatin" in a variety of sentences. We hope that you will now be able to make sentences using this word.
